General Cell Lines and Cell Cultures
Eurofins Discoverx Ready-to-Assay NMU1 Neuromedin U Receptor Frozen Cells, 2 Vials of Cells. (HTS062RTA)
The Ready-to-Assay nMU1 Neuromedin U Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. Neuromedin U) based activation of nMU1R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses nMU1R alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of nMU1R, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen MC5 Melanocortin Receptor Stable Cell Line, 2 vials. (HTS155C)
The ChemiScreen MC5 Melanocortin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. α-MSH) based activation of MC5R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MC5R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of MC5R, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Biochain Institute Inc Paraffin Tissue Section - Human Bladder Tumor: Papillary Transitional Cell Carcinoma, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx PathHunter CHO-K1 mDRD5 β-Arrestin Cell Line, 2 vials. (93-0573C2)
The PathHunter mDRD5 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dopamine) based activation of mDRD5 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mDRD5 and EA-tagged β-Arrestin-2. Activation of mDRD5 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CXCR6 Total Internalization U2OS Cell Line, 2 vials. (93-0886C3)
The PathHunter CXCR6 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CXCR6 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged CXCR6 and a ProLink-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CXCR6 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Section - Human Diabetic Diseased Tissue: Spleen, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
ATCC Listeria monocytogenes; Strain: CFSAN002285
Listeria monocytogenes strain CFSAN002285 is typed as serotype 4c and has applications in enteric, infectious, and zoonotic disease research.
Eurofins Discoverx PathHunter U2OS PTGER1 β-Arrestin Cell Line, 2 vials. (93-0937C3)
The PathHunter PTGER1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTGER1 and EA-tagged β-Arrestin-2. Activation of PTGER1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Escherichia coli; Strain 1100101
Escherichia coli strain 1100101 is a whole-genome sequenced bacterium that was isolated from a respiratory sample. This strain is an NDM-1 reference strain and is resistant to ertapenem and imipenem. The bacterium strain can be used in antimicrobial resistance research, drug development, and respiratory disease research.
American Research Products Inc Human Fc receptor panel 9 x 1MG
A panel of 9 individual proteins consisting of all human Fc gamma receptors, including the allotypic variants, and FcRn. The 9 proteins are CD64, CD32a [167H], CD32a [167R], CD32b, CD16a [176F], CD16a [176V], CD16b [NA1], CD16b [NA2] and FcRn (consisting of FCGRT and B2M). Each protein consists of the extracellular domain fused with a C-terminal tag consisting of the AVI tag, TEV protease recognition sequence and a 10-His tag. All proteins are provided in unconjugated form.
Eurofins Discoverx cAMP Hunter CHO-K1 HTR7A Gs Cell Line, 2 vials. (95-0151C2)
The cAMP Hunter HTR7A Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin/5-HT) based activation of HTR7A GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type HTR7A, a naturally Gs coupled GPCR. Upon activation of HTR7A, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Amsbio LLC NF-kB Leeporter™ Luciferase Reporter-HEK293 Cell Line
NF-kB Leeporter™ Luciferase Reporter-HEK293 Cell Line
ATCC Pfizer Pneumococcal polysaccharide powder Type 56 (d18C) 10mg
Purified pneumococcal polysaccharide type 18C (US Type 56) is manufactured by Pfizer, Inc., for small-quantity distribution by ATCC. The pneumococcal powder type 18C is a component of the current 13-valent vaccine against Streptococcus pneumoniae. The pneumococcal polysaccharide type 18C can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
Biochain Institute Inc Paraffin Tissue Section - Human Bone Tumor: Chondrosarcoma, Well Differentiated, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx Ready-to-Assay D4 Dopamine Receptor Frozen Cells, 2 Vials of Cells. (HTS223RTA)
The Ready-to-Assay D4 Dopamine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. dopamine) based activation of DRD4 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses DRD4 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of DRD4, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.